COVID Vaccine !

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Ajax Bay

Guru
Location
East Devon
All (well nearly all) first and second doses will be administered to Under 40s, so that excludes the use of AZ Vaxzevria. I guess it will continue in use for the catch-up of the very small percentage of the over 40s who decided not to take the vaccine when offered months ago or who didn't come for their second dose when asked / on time. Is that right Craig?
I suspect you haven't an insight into the planned usage (or not) outside the purview of NHSE, so just declaring "not true" lacks nuance.
 

midlife

Guru
Out of interest checked a coupe of our local drop in vaccine centres.

Workington. Pfizer and modern first and second dose
AstraZeneca second dose only

Carlisle . Only Pfizer and Moderna on offer.

I guess if you wanted a second AZ then you have to shop around
 

Craig the cyclist

Über Member
All (well nearly all) first and second doses will be administered to Under 40s, so that excludes the use of AZ Vaxzevria.
Sorry, I don't quite get this sentence. Do you mean that when the time comes for under 40s to get a booster, it most probably won't be AZ?

AZ will be on offer for several groups, and continue to be available for all centres to order. It is also part of the evergreen offer for eligible groups as a first and second dose vaccine.

It is also not clear yet if third doses will be AZ for those who got AZ for doses 1 and 2.
 
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Craig the cyclist

Über Member
But all vaccine types are available to all sites, subject to them having the correct assurance, which they all have for AZ.

They are not doing many AZ at the moment, but it remains available and still a licensed vaccine which sites will administer.
 

classic33

Leg End Member
But all vaccine types are available to all sites, subject to them having the correct assurance, which they all have for AZ.

They are not doing many AZ at the moment, but it remains available and still a licensed vaccine which sites will administer.
There's no-where offering it locally to me. That includes the three walk in vaccination "centres".

"Available to order" doesn't mean much if no-where is using it.
 

Craig the cyclist

Über Member
There's no-where offering it locally to me. That includes the three walk in vaccination "centres".

"Available to order" doesn't mean much if no-where is using it.
If you aren't having it, why does it matter?
 

Ajax Bay

Guru
Location
East Devon
This is a report/study on how breakthrough infections are made far less serious if single or doubled vaccinated.
Johnno - welcome, albeit briefly I fear as we're NACA'd, but I refer you to umpteen trials and studies which determine that the protection against infection is less than against severe infection and worse - so what you say is well known (by those reading this thread, anyway).
Here are the data used by one of the SPI-M papers looking at the July reduction in NPI.
1630616302112.png
 

Ajax Bay

Guru
Location
East Devon
Craig - I know you can add real value.
Saying 'all centres have access to AZ' is meaningless to the vaccinatee. The key info is whether they're offering it. "It remains available." What, locally, do you mean by this? You mean there are supplies somewhere in UK?
Don't see why you attempted an (off-target) pop at @classic33 who has shared the reasons why he was very wary about being vaccinated, bravely went for it and had significant immediate complications. So it does "matter" to him, and maybe more to him than others on this thread whom I suspect are all double dosed.
How about: "For the next month, all (well nearly all) first and second doses will be being administered to Under 40s, so that excludes the use of AZ Vaxzevria." Quite likely that, if the JCVI so recommend, the over 70s will be offered AZ, but currently JCVI have not made a decision on that (see my post above). The JCVI text is:
"For those [immunosuppressed] aged 18 years and over, JCVI advises a preference for mRNA vaccines for the third primary dose, with the option of the AZ Vaxzevria vaccine for individuals who have received this vaccine previously where this would facilitate delivery. In exceptional circumstances, persons who received a mRNA COVID-19 vaccine previously may be offered a third primary dose of AZ Vaxzevria vaccine following a decision by a health professional on a case-by-case, individualised basis. For those aged 12 to 17 years the Pfizer-BNT162b2 vaccine remains the preferred choice, as set out in JCVI advice of 4 August 2021."
I think the studies on vaccine mixing have yet to report, but istr that early data suggested mixing resulted in a greater set of immune responses.
 

Buck

Guru
Location
Yorkshire
Pfizer is now licensed and is branded as Cominarty. There will be some changes to storage and transportation but nothing else and from a patient perspective we’ll just keep calling it Pfizer!

All orders for 3rd dose for W/C 6/9 (and emerging that very likely the same for 13/9) have been cancelled with a potential go-live W/C 20/9. It looks like all 3rd dose may well be Pfizer regardless of 1st and 2nd dose. At present we only have one 3rd dose order line which supports this. *The final JCVI guidance is still pending so everything is up for grabs and AZ may be 3rd dose for housebound and care homes if the transportation of Cominarty is too complex for these cohorts

AZ is now only second (and third?) dose only and IMO we will now see it move to be an export vaccine with our primary being Pfizer followed by Moderna With others as they come on stream.

There is very likely an announcement tomorrow on healthy 12-15 Year olds.
 

Craig the cyclist

Über Member
As @Buck says, planning should all be done by now for booster doses for cohorts 1-9 (+ the evergreen offer) . There is ongoing discussion around HCPs who were vaccinated very early on, but it looks likely they will be included.

The 3rd dose is available as a notional Pfizer vaccine, however the decision to include AZ isn't final yet, and it needs to be made clear that the AZ vaccine is still very much available to order for all sites who have been AZ assured. Buck has said that all 3rd doses for week 6/9 have been cancelled, just to be clear, that isn't quite right, the orders will now be moved on and delivered to sites in time for whenever the programme starts. Doses planned to be administered as part of the current programme (2nd jabs and evergreen 1st jobs etc) will also be delivered in time as planned and won't be cancelled.

AZ can be first dose for some groups, so remains very much one of the 4 licensed vaccines available for use in England (Pfizer (Cominarty), Moderna (Spikevax), Oxford/AZ and the Janssen single dose).
 

Craig the cyclist

Über Member
You mean there are supplies somewhere in UK?
There is a large amount of AZ in the system already, with new vaccine available to order by any sites who have been assured for it to order/draw down on and administer.

You are right that most 1st dose vaccine won't now be AZ, certainly for the current age groups, but there still lots of people who are in the AZ age range and yet to be vaccinated. A surprising amount actually!

How about a fun quiz to lighten the mood (possibly Buck is banned from this)?

There are also some people who are up for getting doses 4 or even 5, not many, but the programme is certainly doing those doses for some people, who may those people be?
 
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