Coronavirus outbreak

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icowden

Veteran
Location
Surrey
Hi @icowden - I can't see the vaccine effectiveness in that analysis. Only the efficacy, which is usually higher. Can you tell me what link I'm failing to click or whatever, please?

Difference between efficacy and effectiveness explained at https://www.gavi.org/vaccineswork/what-difference-between-efficacy-and-effectiveness

Hold on there soldier!

It was @Ajax Bay that challenged my post which stated Efficacy but chose to use the term Effective. As it appeared to be a direct rebuttal of the statistic I provided, I then provided the source of my statistic, albeit one provided by AZ themselves.
 

icowden

Veteran
Location
Surrey
Think you need to do a bit better than a Feb 2021 Astra Zeneca press release based on the Phase 3 RCT trials Jul-Oct 2020 which offered estimates of efficacy, not effectiveness. And that was against the original 2020 'variant'.

Sorry old bean, I thought you were refuting my Efficacy stat which was properly sourced. I don't disagree with your analysis and if you read my post it was an attempt to explain why people get admitted to hospital with Covid even if they have been vaccinated.

The Vaccine is going to become less and less effective as the virus mutates. Let's pop a September lockdown in our diary now shall we?
 

Buck

Guru
Location
Yorkshire
I'm fairly sure an impolite reaction was the reaction she wanted, expected and was prepared for. I wasn't going to let her have the satisfaction of what she wanted; instead I think/hope I annoyed her because she didn't entirely understand what I had said, so she didn't know how to react!


She is probably still trying to spell proximity so the she can look it up in Google on her smartphone!
 

Buck

Guru
Location
Yorkshire
To wear a mask for long periods (or the same mask previously worn on the same day, maybe several times per day) has the obvious negative of you forming a bacteria trap right in front of your breathing-in organs. The moisture from your expelled breath will be absorbed by the fabric or the filling of the mask and this now being moist, will act as a trap for someone else's expelled bacteria, particularly from those going bare-faced.

I know it's not easy for everyone else especially where they are wearing face coverings rather than masks but the NHS IPC guidance on PPE, specifically surgical mask wearing, is for each mask to be "sessional" i.e max half a day with more frequent changes should the mask become uncomfortable (i.e. damp) or otherwise damaged.The thinking behind the change frequency was to stop people not wearing them due to them being uncomfortable etc.
 

Ajax Bay

Guru
Location
East Devon
For example, your first dose gives you a likely 76% efficacy rising to 82% after the second dose and time for that to take effect.

@Ajax Bay that challenged my post which stated Efficacy but chose to use the term Effective. As it appeared to be a direct rebuttal of the statistic I provided, I then provided the source of my statistic, albeit one provided by AZ themselves.
Well since you wish to nit-pick, a first dose doesn't "give you efficacy", the vaccine dose has a protection efficacy rate (I note the AZ press release doesn't say efficacy against what (symptomatic illness?). But efficacy rates estimated in 2020 trials are completely OBE (so why quote them?), and real world effectiveness is the best measure. So 76% is not "likely" it's just wrong - except as an example, I suppose, but why not say 99%.
Here's the Lancet paper (8 Dec 2020) where the RCT trial results are reported: https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(20)32623-4/fulltext
"Oxford/AZ vaccine efficacy for more than 14 days after the second dose in the standard dose (SD)/SD cohort was 62·1% [against symptomatic infection]."
Beware of press releases. Published peer-reviewed papers are far more reliable.
Of course we now know that the efficacy estimates were at variance with real life effectiveness.
Here's an even more up-to-date study (today): reported here (with link to NEJM): https://www.medscape.com/viewarticle/955207
 

Johnno260

Guru
Location
East Sussex
Apart from that guy the other day my only other encounter with an unmasked was someone reaching over me to grab some milk, even outside of Covid times it would’ve annoyed me as one he was so close I thought he was about to proposition me, and the fact I could smell he had onions and sausages for lunch! lol
 

mjr

Comfy armchair to one person & a plank to the next
How does not wearing a mask from 3 days ago create supermarket shortages then?
Because, as you know, masklessness and so on was rife from Boris's announcement on the 12th, followed by surging cases, followed by lots of people quarantining.
 
Because, as you know, masklessness and so on was rife from Boris's announcement on the 12th, followed by surging cases, followed by lots of people quarantining.


In 3 days the country has ground to a halt due to everyone suddenly getting Covid, taking a test that's proved positive and then been in contact with that many people the food has failed to get on the shelves?

Wow!

Can't really complain I suppose, that's what it was designed for.
 
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al78

Guru
Location
Horsham
In 3 days the country has ground to a halt due to everyone suddenly getting Covid, taking a test that's proved positive and then been in contact with that many people the food has failed to get on the shelves?

Wow!

Can't really complain I suppose, that's what it was designed for.

Which country is that? Certainly not the UK, nothing has ground to a halt in my region nor where any of my family live. Shops are open and public transport is operational.
 
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