I do not expect to see chain drops on Di2 and the typical times I have seen them the setups have not been setup as instructed in the manual, or have non shimano cassettes and chain rings, which is why that was one of the first things I asked
.
As a bit of a weight weenie, I have tried a number of billet cassettes and found they impacted shifting negatively im now running a shimano cassette again.
On Shimano cassettes I can shift down and up while on power, it seems that people with sram cassettes and other brands need to back off and not put a load on the pedals to shift in an effective manner at times. Although you can 'touch' the shifter on Di2 with a non shimano cassette you get better success pressing the shifter and holding it for a second or two... fast shifts cause chain throws.
Ultimately I would advise moving to a full Shimano setup