I've just swapped my Spyre calipers for 105 7020 STI hydraulics and it's a massive massive improvement. Not that the sypres were bad (they do need attention on a regular basis to keep them in optimum set-up however), it's just that the hydraulics (as you'd imagine) are so much better. Running them with the stock L02A pads on 140mm rotors (on an Orro Pyro). Maybe it's my legendary wrenching but they seem to have bedded in instantly, and no noise from them in the damp. Ummed and erred about the upgrade for a while but then found a full set on Merlin for £325, so jumped at the chance..
https://www.merlincycles.com/shiman...flat-mount-disc-calipers-11-speed-119868.html
More assured now that should I need to stop in a hurry whilst on the hoods I can do so. The modulation on offer makes the very much increased stopping power very manageable.