As pointed out, in severe extremes, use of a twin system may have issues, but with he average cyclist, a carefully set up system will make no difference. Setup is easy with a slightly different tension on each cable allowing a difference between front and back brakes
Hydraulics are different as there needs to be sufficient fluid movement, which may not be achieved with standard reservoirs and pistons
Magura used to do the "Big" a dual hydraulic operated from a single lever which found limited popularity with recumbent trikes
this came up on another forum, pretty sure it was on here too.
as has been said, the bias varies immmensely but for the averga cyclist not doing steep descents, a compromise could be worked out and would work.
about one lever not being able to push enough fluid. I have thought about this and it may not be the problem you'd think it is. when you release the brake lever, if goes back by means of a spring in the master cylinder and will pull fluid thus moving the pads off the disc. if you have two callipers off the one master, all that will happen is the pads will move out less so the pad-disc clearance is less than if one calliper was connected.
now different make/model of brake lever and calliper have different piston diameters (I am using Shimano XT lever with Magura calliper, the Magura calliper having a larger piston area that the lever is designed for) but it works - there is no excessive travel as you would expect since the pads don't move out as far.
so mix and match the lever and calliper could end up with a working system - the smaller clearance means that any warp in the disc would mean they will drag on the pads.