Without wishing to seem argumentative - why is that?
Surely you have to do the same amount of work, either pedalling slow or fast, so the CV system has to deliver the same fuel and oxygen, so has to work just as hard in both cases. Or am I wrong?
Now, if your slower cadence was brutally tooth-grindingly slow then maybe I could understand it, due to different metabolic pathways - maybe anaerobic work being done. But if slow is say 60 and high is say 90 then I imagine the metabolism is similar in both cases.
I've heard this stated before and I've always wondered this. If the CV system gets an easier ride at lower cadences then surely that implies that they are more efficient?
I'm not a biochemist so I don't really know what I'm on about.