Get the top groupsets, but don't get the top sprocket set - too expensive / won't last.
Record is getting stupidly expensive, the same for the new 7900 Dura Ace. The bits that could fail easily might be shifters, and both groupsets shifters are very expensive.
My Dura Ace kit is 17 years old and works faltlessly - it was definately worth the money, but I fear the newer stuff has traded durability off against weight. The 7400 Dura Ace that I have isn't particularly light, but it is 'bomb proof'.
There would be some bit's of a bike that I'd trade weight against durability - I perfer durability...i.e. I'd never buy a £1000 wheel set, more like £500 if I was getting a bike like that - and a wheelset that had been well tested and had a name for 'bomb proofness'
If you can afford it, and it's going to be your best bike - not the daily hack, then go for it, but be prepared for expensive parts when/if needed.
How about the new Colnago frame - CF4 I think