Suggesttions.
If you are wearing underwear below the padded shorts, rtaher than 'going commando' ditch the underwear as the seams can cause chafing
Clean pair of shorts for every day. Effectively wear a day, wash. Be ultra, ultra clean where your nether regions are concerned.
Lubricate: Vaseline, Sudocreme, various brands of chamois creme - whatever takes your fancy.
Make sure your saddle height is correct.
On a long ride - take some creme with you so that you can re-apply as necessary.
Hope this helps.