COVID Vaccine !
- Thread starter kingrollo
- Start date
Page may contain affiliate links. Please see terms for details.
Rusty Nails
We remember
- Location
- Living in the slow lane
I've ditched the masks and am off to a crowded pub for a pint to celebrate.
Or should I wait a while?
OP
OP
kingrollo
Guru
So controversy on the Oxford trial data. Differing reports - with some saying a higher does gives 90% protection - while some saying a lower dose. and some reports suggesting the higher number are only achieved in the under 55 years - its effectiveness for the rest of us could be as low as 62%
winjim
Smash the cistern
It's almost as if they've been in a bit of a rush. But the reports I've seen say it's the half-full dose which is most effective(in <55s). Interestingly the FT quotes a study participant who was informed of the half dose cockup in July. I received no such information so I assume that I'm in the full dose cohort.
roubaixtuesday
self serving virtue signaller
I really wouldn't overthink the "controversy" over the Oxford trial.
The results look good.
The endpoint will have been agreed in advance with the regulatory agency (always is for phase 3 trials, not just this one)
Their lawyers and regulatory experts would not have allowed them to make a misleading press release - its illegal under financial law.
There's lots of detail unclear from the press release. This isn't unusual for a phase 3 trial. The trial is complex because it covers multiple countries. Again, not at all unusual.
It's always possible that something surprising and negative will emerge, but I wouldn't lose sleep over it.
@winjim I think the dosing error was in the earlier phase I trial. When the data from that looked good, it was deliberately included in the phase 3. Could be wrong.
The results look good.
The endpoint will have been agreed in advance with the regulatory agency (always is for phase 3 trials, not just this one)
Their lawyers and regulatory experts would not have allowed them to make a misleading press release - its illegal under financial law.
There's lots of detail unclear from the press release. This isn't unusual for a phase 3 trial. The trial is complex because it covers multiple countries. Again, not at all unusual.
It's always possible that something surprising and negative will emerge, but I wouldn't lose sleep over it.
@winjim I think the dosing error was in the earlier phase I trial. When the data from that looked good, it was deliberately included in the phase 3. Could be wrong.
winjim
Smash the cistern
Can't find the actual statement but reports are that it was 'later phases' of the trial. AIUI they only switched to using two doses partway through phase 2/3. We were recalled and told they had done this, we originally only signed up for one dose. This may be because they were looking at data from phase 1/2 though.
OP
OP
kingrollo
Guru
Me too - I've been WFH since march. But now pressure is mounting to get me back on site (hospital env) - my shielding letter protects me until next week - after that the prospect of mingling with patients doesn't thrill me - as an asthmatic !
Not if you don't want it to get warm and flat ...
Ming the Merciless
There is no mercy
- Location
- Inside my skull
There aren’t differing reports from the Oxford people. It’s just newspaper editors getting confused. But then we know they're not the brightest when it comes to getting the facts right.
Watched an interview with Dr. Ingmar Hoerr last night. He is the biologist who discovered, more by luck than design, the potential use of RNA for vaccines. He had an infectious (sorry!) enthusiasm talking about the discovery, which his professor initially didn't believe!
It was interesting how he financed Curevac, the company researching this - initially Dietmar Hopp very rich founder of SAP put up a couple of €million, and later also the Bill Gates Foundation. That should whet the conspiracy theorists appetite, but without this investment the technique could not have been developed.
The most interesting point to me as a complete layman (thicko!) in this kind of thing was the fact that the new vaccines being developed against corona using RNA ought to be safe from long-term effects. It (RNA) is so unstable that after injection within a very short period of time it just disappears. It survives only long enough to trigger the body's immune system and is then gone. The body, however, remembers it and reacts accordingly if it encounters the corona virus.
It was interesting how he financed Curevac, the company researching this - initially Dietmar Hopp very rich founder of SAP put up a couple of €million, and later also the Bill Gates Foundation. That should whet the conspiracy theorists appetite, but without this investment the technique could not have been developed.
The most interesting point to me as a complete layman (thicko!) in this kind of thing was the fact that the new vaccines being developed against corona using RNA ought to be safe from long-term effects. It (RNA) is so unstable that after injection within a very short period of time it just disappears. It survives only long enough to trigger the body's immune system and is then gone. The body, however, remembers it and reacts accordingly if it encounters the corona virus.
oldwheels
Legendary Member
- Location
- Isle of Mull
Perhaps it is fake news but the Oxford vaccine is doomed. Apparently in Scotland at least it must have a union jack printed on the capsules. Taxpayers money is to be spent on political posturing.
Moon bunny
Judging your grammar
- Location
- Basking in my own brilliance.
