There's some of top tips in this thread
Despite being moderately handy with adjusting gears, brakes etc. I find it's hit and miss for me in terms of replacing tyres and tubes. I know the theory but don't have the knack sometimes. Mainly in terms of getting tube and tyre back on. As an example, I tried putting some Marathons on a mountain bike. It took me nearly 45 minutes to do one, but only 10 minutes to do the second. I guess practice makes perfect - or nearly competent at least :-)
I'm not sure I'd manage without levers, as I struggle for strength in my fingers. However, I always check that the tube isn't trapped between tyre and the rim before inflating properly. Not sure if that mitigates the issue or not.
I've just invested in some spare tubes, a saddlebag and a repair kit so I can start venturing further afield, but not looking forward to having to use them in anger. I've got into the habit of topping up/checking tyre pressures before setting off.
There are some good videos on you-tube. I found looking for one against the tyre name helpful. Not sure if they all have their own quirks but it worked for the marathons.