I`d say that washing the natural oils from the skin over 30 odd years has been my main problem. At work using swarfega at snap time and at going home time. Great for removing grease but harsh on skin.
Also, I used to work on my own car/tinker in the garage/welding etc up until recently, so in the house it was usually loads of fairy liquid. I`m not convinced about that 60s advert "hands that do dishes are as soft as" whatever it said. My hands are soft, but the backs of them look like dried prunes. I should have wore gloves.