Assuming Froome doesn't lose anytime in the first week including the mountain stage on the Sunday then that will set him up for the TT where he should be able to put serious time into rivals.
There's a tough mountain stage the day after the TT but it looks like the Vuelta will be won or lost in stages 14,15,16 at the back end of week 2. As seen in the tour anything can happen though and it'll probably be very close going into the final mountain stage.
For Quintana to win it'll probably be how much he can limit his losses in the TT and see if he can distance Froome early on. If Froome rides himself into form and gains time in the TT it could be curtains for everyone. Ofcourse Bertie's secret training may do both of them, haha
Can't wait for this!