Nitrous oxide doping.

[Gasman]

Quite. OP, are you sure you're not confusing nitric oxide with nitrous oxide? If that's the case then maybe a toot of poppers is what you need .

Plus, if you're using it in training and it's not proscribed then why be all secret squirrel about it anyway? Just hook up a tank and chug it down.

No, I think he's got it the right way round. Nitric oxide (NO) is a fairly toxic atmospheric pollutant although physiologically, it also turned out to be Endothelium-derived relaxing factor. Inhaling it in very low concentrations can cause dilatation of pulmonary vessels improving blood flow through the lungs and oxygen carriage. This would, however, require equipment slightly more sophisticated than a pocket sized canister.

Nitrous oxide (N2O) is a mild analgesic and weak anaesthetic. The 'intoxicant' effects are not due to N2O itself but are a result of inhaling it in such high concentration that the user ends up receiving insufficient oxygen and suffering from partial asphyxia. I suspect that this would more than cancel out any performance enhancement due to the user feeling a it 'high'.

 

[Profpointy]

No, I think he's got it the right way round. Nitric oxide (NO) is a fairly toxic atmospheric pollutant although physiologically, it also turned out to be Endothelium-derived relaxing factor. Inhaling it in very low concentrations can cause dilatation of pulmonary vessels improving blood flow through the lungs and oxygen carriage. This would, however, require equipment slightly more sophisticated than a pocket sized canister.

Nitrous oxide (N2O) is a mild analgesic and weak anaesthetic. The 'intoxicant' effects are not due to N2O itself but are a result of inhaling it in such high concentration that the user ends up receiving insufficient oxygen and suffering from partial asphyxia. I suspect that this would more than cancel out any performance enhancement due to the user feeling a it 'high'.

I don't think the 2nd part (acting as an asphyxiant) is right at all. It has a proper biological effect. Obviously it would be an asphyxiant as well if you dropped the O2 below 15% or whatever but that would be a fine and dangerous line to tread.

 

[Profpointy]

Do you know what a 'gasman' is?

Someone who comes to the house after you've "painted over the gas-tap and couldn't turn it on"

 

[slowmotion]

Wouldn't Amyl Nitrite be a better bet? For the final sprint to the line, your heart would be pounding like a drum and a lot of your blood vessels would be extensively dilated. The unfortunate side-effect of an extremely relaxed anal sphincter wouldn't really be much of a problem since, on the sprint, your bum wouldn't be anywhere near the saddle.

It's got to be a winner, and a lot easier to conceal than a gas cylinder.

 

[winjim]

No, I think he's got it the right way round. Nitric oxide (NO) is a fairly toxic atmospheric pollutant although physiologically, it also turned out to be Endothelium-derived relaxing factor. Inhaling it in very low concentrations can cause dilatation of pulmonary vessels improving blood flow through the lungs and oxygen carriage. This would, however, require equipment slightly more sophisticated than a pocket sized canister.

Nitrous oxide (N2O) is a mild analgesic and weak anaesthetic. The 'intoxicant' effects are not due to N2O itself but are a result of inhaling it in such high concentration that the user ends up receiving insufficient oxygen and suffering from partial asphyxia. I suspect that this would more than cancel out any performance enhancement due to the user feeling a it 'high'.

So where's the performance enhancement? I can see that there might be a benefit to vasodilation, which is why I wondered if he might have his nitric and nitrous oxides mixed up. Of course you wouldn't directly inhale NO, but rather take something like nitroglycerine, or alkyl nitrates, or viagra, or even just eat a funload of beetroot.

 

[Profpointy]

Wasn't there a bit of a hoo ha at the winter olympics a few years back where the champion snow boarder in the trick-skiing category was disqualified for smoking dope. Whatever virtues are claimed for cannabis I can't recall anyone suggesting performance enhancement was among them. To be fair to his rivals I think they all went on strike till he was re-enstated.

 

[I like Skol]

I'm not going to repeat what I said but at the risk of a telling off I will openly state that I still stand by the sentiment of my previous, unmoderated post in this thread and the opinions expressed.

 

[slowmotion]

Wasn't there a bit of a hoo ha at the winter olympics a few years back where the champion snow boarder in the trick-skiing category was disqualified for smoking dope. Whatever virtues are claimed for cannabis I can't recall anyone suggesting performance enhancement was among them. To be fair to his rivals I think they all went on strike till he was re-enstated.

I think their argument was that THC was actually an integral part of snowboarding and that it was totally unreasonable to punish its use.

Probably an urban myth, but who cares?

 

[winjim]

I think their argument was that THC was actually an integral part of snowboarding and that it was totally unreasonable to punish its use.

Probably an urban myth, but who cares?

Ross Rebagliati. He now runs a medical cannabis company or something. They found THC in his system, but it wasn't actually a banned substance.

https://www.cyclechat.net/threads/coppi-fignon-pantani-and-recreational-drugs.173150/post-3497832

 

[winjim]

So where's the performance enhancement?

Something like this potentially? Stimulate production of HIF1 and therefore EPO?

https://www.researchgate.net/public...ors_and_Erythropoietin_or_Nothing_but_Hot_Air

 

[dianelc]

What are the effects of nitrous oxide?
Nitrous oxide is depressant-type drug, which means it slows down your brain and your body’s responses.

The effects of nitrous oxide vary depending on how much has been inhaled but they include:
• Feelings of euphoria, relaxation and calmness.
• Dizziness, difficulty in thinking straight and fits of giggles/laughter.
• Sound distortions or even hallucinations.
• In some people, a headache can be an unwanted immediate effect.

http://www.talktofrank.com/drug/nitrous-oxide

I'm no expert on hard training, but there are quite a lot of things there that don't strike me as particularly helpful to anyone wanting to get faster...

It also makes many people feel sick!! I think that might slow you down.

 

[Profpointy]

I don't think the 2nd part (acting as an asphyxiant) is right at all. It has a proper biological effect. Obviously it would be an asphyxiant as well if you dropped the O2 below 15% or whatever but that would be a fine and dangerous line to tread.

For @Gasman - obviously I don't want to argue with someone who's presumably an anaesthetist but I was given to understand than Entenox has a psychological effect as well as / instead of pain relief, yet is 50% O2 - which is plenty to say the least. Is your asphyxiant point maybe some technical meaning - akin to say CO, which blocks oxygen takeup (or something like that)?

 

[Dec66]

It's a mild anesthetic. It comes in canisters that look exactly like the co2 canisters for inflating the tyres. All you would have to do, is pick the canister out of your jersey, behind a 'gel' or energy bar, pierce the top ( again easy to do) inhale the gas, and bingo, no more stingy legs, and a high. That would allow you to train harder and longer ( like 'roids, and EPO ) but not leave any trace, and Nitrous isn't proscribed anyway ( yet ). So that means you wouldn't even need to be subtle. No one would raise an eyebrow, about a cyclist disposing of empty canisters anyway.

I know what it is and what it comes in

You see hundreds of canisters round here, dumped together. And that's the point; the effect of one canister lasts a matter of seconds, not long enough to have any performance benefit if inhaled.

Besides, wouldn't it be obvious when riders were peeing themselves laughing at the point of maximum intensity?

 

[Racing roadkill]

So where's the performance enhancement? I can see that there might be a benefit to vasodilation, which is why I wondered if he might have his nitric and nitrous oxides mixed up. Of course you wouldn't directly inhale NO, but rather take something like nitroglycerine, or alkyl nitrates, or viagra, or even just eat a funload of beetroot.

You have to avoid anything that is proscribed, or would leave trace metabolites that are. And yes I do know the difference between Nitric and Nitrous oxides, and yes I meant Nitrous. Taking poppers would leave proscribed metabolites in the blood. I'm talking about using it to increase training benefits, not in the event itself, much like EPO doping, there's not much point in using it during the event. There was a recent study completed, using deliberately EPO doped riders, versus placebo doped riders, versus clean riders, up in the Alps. The results seemed to show no discernible gain to using EPO 'on the day' it works best by allowing the rider to train longer and harder in the run up to the event.

 

[rich p]

I seem to have stumbled into an alternative parallel world. It's quite amusing really, much more fun than reality