If the whole wheel is built to fairly low tensions then, modern rims being pretty strong, the wheel won't go much out of true. However slack spokes will break more quickly. Tighten them until they feel about even, then go around the wheel, starting somewhere obvious such as the valve hole, to true it. You don't even need to take the tyre off for this. If you have vertical drop-outs, it's easy enough to true the wheel in the frame - clip some sort of guide either side on the chainstays.
If spokes are loosening regularly, try upping all the tensions by a quarter to half a turn. You can try even more if still they feel a bit slack. Some truing will almost certainly be required afterwards.