Having only rode triples and doubles before the compact took me a while to get used to.
my biggest early mistake was waiting to turn right seeing an almost big enough gap in the fast traffic ,going for it then realising I was in 34 30 with my feet doing 200 rpm and bike going agonisingly slowly across the junction .
For a few months I thought it a horrible set up but now a year later I am quite happy with it.
I generally avoid large large or small small combinations Theres no point putting the extra stress on your chain if you don't have to.