I agree with pp that one of the best things you could do is get your bike serviced, so it's working as it should and and set up right for you. In terms of gears, I only avoid the opposing pairs of gears, I use all the rear gears while in the middle ring at the front. A lot of ratios can be achieved in different ways, so it often depends what you're going to want to do next e.g. if there's a hill coming up you might want to be in the smallest ring at the front so you can easily access all the lowest gears.
Very well done for getting back on a bike (more than once!). I know how tough it is, but it's so rewarding.
Very well done for getting back on a bike (more than once!). I know how tough it is, but it's so rewarding.