According to Strava (which may not be all that accurate - although I have put in accurate information pertaining to age, weight etc) it tells me that on my rides, on average - I put out between 150 - 200w and that when cranking hard uphill it can go up to bursts of up to 550w. From what I can tell, that amount of power is pretty modest.
When people talk about needing stiffer frames, stiffer wheels and stiffer cranks - in your opinion, would a person weighing in at just under 80kg (me) and putting out a relatively small amount of power cause even a cheaper frame, wheel or crank to flex? If the answer is no, then from my perspective, unless I'm riding a really heavy bike - making changes to components is unlikely to result in any performance gains. If on the other hand it's the case that my weight and power output would cause the components mentioned above to flex and therefore absorb a significant amount of pedalling energy - then there could be a case for upgrading.
I'll pop a thought in in here. Frames and forks are designed to flex. If they were utterly rigid, they would be awful to ride, so they are designed to flex in certain areas, some more than others. To make an Alu or Steel bike stiffer, the tubing would be thicker which adds weight. Tricks can be done with tube shaping, but that is essentially it. Carbon has the benefit of being able to be stiff and also light.
On the flat when I'm just cruising along, it would make absolutely no difference which bike I was on, the top speed I could achieve would be the same (drag rules top speed, not weight). However, the bike with lighter wheels would be easier to accelerate.
When climbing, and you are putting out all the power you can, you will be flexing parts of the bike and wheels (yes, even us modest riders). If some areas (BB and chainstays most often) can be stiffened then more of your energy goes into turning the wheel. Add lighter wheels to that and the difference is noticeable.
IMO, if I put the new wheels on my Defy, I would see 90% of the improvement the new bike has shown, but over a decent distance ride, the overall speed gain will be very small. The only further improvement on the new bike would be an even lighter set of wheels, making it a little easier again, but it's ultimately up to me, my legs and my fitness to go any faster. It's all the bike I will ever need.
I wasn't gonna be buying the Advanced 2, I was after something for £1400, but when you're offered a £2k bike for £1600, it would be rude not to