One thing not mentioned is the cage movement when on a large x large the cage will be at it most forward postion and if the chain is a little short can lead to noise plus it also at its most extreme angle side to side, I know my 105 set up doesn't like my 52x24 or 27 (though it works), and the chain is the right length, on my middle ring (40th )I can use all 10 gears and my small when I use it. I do tend to avoid the high end, again if the chain is to long the cage has too much slack to take up and the chain can rub on the cage.
@Big_Dave depends how you set the front up, choosing the right chain rings can give you half gear stepping between gears, not as critical as it used to be with so many on the rear these days.
I have on my 30sp only 4 that are duplicates as such.
View attachment 55090
As my avg gear inch is about 60-61" you can see that the 40x17 is about as straight as I can get for a chain line, try that on a double.