Get a spirit level and hold it down the centre of the chain when in largest sprocket. Should be perfectly vertical in that plane. There are of course tools to measure this and to apply correction. It does not look far off so, again, I'd be surprised if that was the cause of the "irregular noise". Why 'irregular' if the cage is out of vertical?
As for
@Gunk 's 'that is not a knife', 1000s of kms (as in 15+ depends on nature of terrain and cleanliness regime) of use will turn the jockey wheels into ninjas, but that assumes they have kept turning (ie been maintained, once in a while).
@Gunk 's imaged wheel has stopped turning and the rider has failed to notice the additional friction, a bit of noise and the cage 'kicking around'.