A 12-34 cassette is a fairly wide range and your RD would have to be up for that.
But you'll find that you have quite an overlap on gear ratios. A 34x12 for instance is very similar to a 50x18. Always best to switch to the big ring well before moving down to the smaller sprockets with the small chain ring, then chain slack wont be a problem.
I've heard the expression "Shimano Shuffle" before. Basically when speed is increasing, change up on the front and two down on the rear when you are getting past the middle sprockets. When slowing, do the opposite, down on the front and two up at the rear. You need to study gear tables to make sure that you are getting progressively higher or lower rations when you do the "shuffle".