One of the main uses of chamois cream is not so much to provide comfort but to prevent infections, boils, saddle sores etc. The inside of a chamois in your shorts can become an unhygenic place, especcially if you do not change them every day or you are on a very long ride. On short rides, I do not use it at all. Also some chamois in shorts require a very low temperature wash and that is not enough to kill the bacteria off, one pair of mine requires a cold water wash, so basically its just getting a rinse with some soap powder, so when I wear them next, their just clean dirty shorts with a good chance of picking up an infection