I've been on an ACE inhibitor (Ramipril) for four years, as well as statins and other cholesterol reducing drugs. I ride about four and a half thousand miles each year, mainly commuting. I've had absolutely no adverse side-effects at all. I used to be opposed to long-term medication but I have no objections at all to it now. If you have problems with the drugs that you are prescribed, your GP can find alternatives, or you yourself can decide to stop. Personally, I would give it a shot and see how it goes. Good luck.