You're going to have to let us have some idea of the budget you have in mind.
However generally speaking, spec for spec, regular hand built wheels from a well respected builder, have the edge until you get somewhere around the £400 mark.
However, hand built wheels don't have any 'bling' factor. Therefore the designer wheels have their proponents at all price points from about £100 upwards, despite something lighter, stronger, more reliable, more durable or easily maintained being availble at the same price in the more mundane hand built world.