It's likely that the giant defy wheels have sealed cartridge bearings, they are unserviceable, so if the bearings feel rough or need a little bit of effort to turn them then the bearings need to be replaced.
Recently replaced the bearings in a set of Fulcrum racing 7 wheels, they were feeling a bit gritty, new bearings sourced and fitted and the wheels are smooth and spin well again.
I used 6001 2RS FAG bearings, your bearings may be different.