↑ this and this ↑
Might sound obvious, but if you don't like it aesthetically, or it doesn't fit quite right then no matter how much you kid yourself, you won't ride it.
I'm also 6'5" and struggle with the modern fetish for compact frames as I really don't like sloping top tubes, and finding a modern bike that has a straight, or at least straightish top tube isn't always easy. FWIW my road bike is a 60cm Cannondale CAAD10 and I love it.
Also stating you want a 'new road bike' is quite a generic thing, do you want sporty geometry or relaxed geometry, as you don't mention any specific models of the manufacturers you've listed, this would help people advise you better, but at the end of the day you can have a world of knowledge but it's still got to appeal to your eye and fit you properly.
Also don't get hung up componentry either, you specifically mentioned Ultegra, but in doing so you might overlook a 'better' bike that has 105, or Sram or something else, again knowing models you're interested in would help folk give you opinions and even alternatives.
Good luck and welcome to CC