I've tried Muc-off, Orange and Stans and have no particular horror stories to report, but I'm running 28c tyres at ~65psi, so not super high pressures. Mostly it's glass pieces and thorns that get through and and i've never experienced a loss of pressure from those with any of my choices, the first time I notice is when I check the tyres when cleaning the bike. Currently using Stans regular sealant.