EDIT2: just reread the OP properly and seen it's not about the spacing at the hub but the position of the tyre and rim at the BB end of the chainstays.
(Just looked at my Fulcrum R5 and thats how mine is too. The non-drive side flange is not as far out as it could be, and there is a 'gap' between it and the dropout. This is presumably about having it far out enough to give lateral stiffness but not so far as to have spoke tension too unbalanced; a wheelbuilder type would be able to explain more clearly. The drive side flange is as far out as the cassette will allow.
If the tyre is central between the chainstays just behind the bottom bracket, and again at the brake bridge when the wheel is fitted both ways round, and the gears work fine (when it's the right way round obv.) then I think the frame and wheel must both be true.
EDIT: also just remembered, the dropouts on a road bike are meant to be 130mm apart, which is easy to check.)