I have ridden the first few miles from Brecon on a road bike with 23c tyres no problem. also ridden a section near Pontypool also on road bike no problem.
I have done part of this, I went from Newport to Abergavenny, that was about 30 miles. Most of that section is on the rough/gravelly side, once you get past the major towns. I did it on a hybrid, I wouldn't consider it on a road bike unless you enjoy punctures. I don't know about the rest of the route though. Very nice route, if you do it on an appropriate bike.
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