The knobblyness of a tyre is irrelevant to it's puncture resistance really.
This is for the bike in your
other thread I presume? Also, have I got it right that you're mainly riding on the road? If this is the case I'd suggest something like a
Schwalbe Marathon which is very puncture resistant or the
Marathon Plus which is super puncture resistant (but apparently a little tricky to fit).
I don't know how much you are intending to spend. If you wanted something a little cheaper I've found
Continental TourRide is a decent tyre with good puncture resistance (only just had my second puncture in well over 3500 miles on mine).
There are lots of other alternatives out there too.