Slightly biased opinion (I have a Defy 2), but the Defy has slightly easier bottom gearing for hills and also mudguard mounting points (for specific Defy guards) which would put it slightly ahead imho.
I have done a couple of 100 milers on my Defy and although the seat hurts after 60+ miles, the frame and seating position are very comfortable over any distance...for me.
If huge hills aren't an issue in your area, then they would appear much the saem on paper - give them a try, one will 'fit' better than the other.