Debateable! My hybrid has 35's, my road bike has 23C tyres. I still find myself taking the hybrid on rides in preference to the road bike and showing a good proportion of riders a clean pair of heels. On a recent forum ride I received a comment from one of the other riders (totallyfixed?) along the lines of 'you do like to hit the potholes don't you?' My answer to this should have been - "actually, I don't give a damn because I ride 35c tyres on 29'r MTB wheels so I KNOW they will shrug off whatever I throw at them". I can't remember who said it (Murray walker maybe?) but one of the F1 pundits used to regularly say a quote that I repeat to myself almost daily "To finish first, first you have to finish!". Basicaly, It doesn't matter if you ride the skinniest, lightest, fastest eye-candy steed on the market, at the end of the day, reliability and dependability will win through. It's no use subjecting yourself to an uncomfortable ride and endless pinch punctures if this means you lose time and lose the desire to ride your bike. The guy who just keeps going will win!
Don't get me wrong, the road bike on 23c tyres is exciting to ride and is marginally quicker (typical trip times on a 10 mile commute) but when I have to spend a long day in the saddle and cover BIG mileage I will normally plump for the hybrid on 35's