The wonderful Three From Leith podcast is always a good bet ...
(though I'm taking a podcasting break just now and starting again in March).
Try 'Top Of The Pods' (
www.topofthepods.com) with Rob and Jon too - now no more, but the shows are all still there for listening to. Two guys, a listener-submitted top ten of something-or-other, and much hilarity.
The Bob & AJ Show is another fave of mine; two Canadians who get together for the odd discussion and music. Doesn't sound like much from that description, but they're great company and usually very funny.